Naspm trihydrochloride

SKU: orb1309353

Description

Naspm trihydrochloride

Research Area

Neuroscience, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 1049731-36-3
• MW: 479.91
• Purity: 99.75%
• Formula: C₂₂H₃₇Cl₃N₄O
• SMILES: [H]Cl.[H]Cl.[H]Cl.NCCCNCCCCNCCCNC(CC1=C2C=CC=CC2=CC=C1)=O
• Target: iGluR
• Solubility: H2O:50 mg/mL (104.19 mM);DMSO:6.4 mg/mL (13.34 mM)

Bioactivity

• Target IC50:
  AMPAR:0.33 μM
• In Vitro:
  NASPM selectively suppressed the inwardly rectifying and Ca(2+)-permeable AMPA receptors expressed in type II neurons. It had no effect on AMPA receptors in type I neurons. The blocking effect of NASPM on the Ca(2+)-permeable AMPA receptors was use and voltage-dependent. When the effect of NASPM reached a steady state, current responses induced by ionophoretic applications of kainate, a non-desensitizing agonist of AMPA receptors, in type II neurons were suppressed by NASPM in a dose-dependent manner at -60 mV (IC50 0.33 microM, and Hill coefficient 0.94). The response to kainate recovered partially after washing out NASPM. NASPM did not affect the Ca(2+)-permeable AMPA receptors when the neuronal membrane was held at potentials more positive than +40 mV. Furthermore, the blockade by NASPM which was attained at negative potentials was transiently removed by shifting membrane potential to +60 mV for 5 s together with a single ionophoretic application of kainate.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

1-Naphthylacetyl spermine, 1-Naphthylacetyl spermine trihydrochloride, 1-Naphthylacetyl spermine Trihydrochloride, AMPAR, Naspm, Naspm trihydrochloride, Naspm Trihydrochloride, Inhibitor, inhibit, Ionotropic glutamate receptors, iGluR

Compound Identifiers

PubChem CID

16219727