NAMPT inhibitor-linker 1

• Catalog Number: orb1987909
• Category: Small Molecules
• Description: NAMPT inhibitor-linker 1, a drug-linker conjugate for ADC, integrates an NAMPT inhibitor (as a payload) with a linker. In the formulation of ADC-3, it pairs with an anti-c-Kit monoclonal antibody, demonstrating strong efficacy against c-Kit expressing cell lines, specifically GIST-T1 and NCI-H526, where it exhibits IC50 values of <3 pM and 9 pM, respectively.
• Target: Drug-Linker Conjugates for ADC
• MW: 668.71
• CAS Number: 2241019-57-6
• Formula: C₃₆H₃₇FN₆O₆
• SMILES: Fc1cc(NC(=O)[C@H]2C[C@@H]2c2cccnc2)ccc1CNC(=O)c1ccc(cc1)N1CCN(CC1)C(=O)CCOCCN1C(=O)C=CC1=O
• Storage: -20°C
• Note: For research use only