NAMI-A

SKU: orb1706932

Description

NAMI-A is a ruthenium-based small molecule that selectively targets metastatic cancer. It functions by inhibiting tumor cell adhesion and migration, as demonstrated in both in vitro and in vivo metastasis models, making it a valuable tool for oncology and metastasis research.

Research Area

Cardiovascular Research, Signal Transduction

Key Properties

• CAS Number: 201653-76-1
• MW: 458.18
• Purity: 98.00% (May vary between batches)
• Formula: C₈H₁₅Cl₄N₄ORuS
• SMILES: [H+].O=[S](C)(C)[Ru+3]([Cl-])([Cl-])([Cl-])([Cl-])[N]=1C=CNC1.N=1C=CNC1
• Target: FAK
• Solubility: H2O:8.28 mg/mL (18.07 mM)

Bioactivity

• In Vitro:
  NAMI-A can significantly affect tumor cells with metastatic ability. The half-life of NAMI-A elimination from the lungs is longer than for the liver, kidney, and primary tumor. NAMI-A bound to collagen is active on tumor cells as shown in vitro by an invasion test, using a modified Boyden chamber and Matrigel, and it inhibits the matrix metallo-proteinases MMP-2 and MMP-9 at micromolar concentrations. The ruthenium drug NAMI-A inhibits the adhesion and migration of colorectal cancer cells. NAMI-A decreases α5β1 integrin expression and FAK auto-phosphorylation on Tyr 397.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

NAMI A, NAMIA, NAMI-A, FAK

Quick Database Links

Gene Symbol

FAK