Nadolol

SKU: orb1225078

Description

A non-selective beta-adrenergic antagonist with a long half-life, used in cardiovascular disease to treat arrhythmias, angina pectoris, and hypertension. Nadolol is also used for MIGRAINE DISORDERS and for tremor.(In Vitro):In human embryonic kidney 293 cells, (-)-Epigallocatechin gallate (EGCG) competitively inhibits OATP1A2-mediated uptake of Nadolol with a Ki value of 19.4 μM. With respect to Nadolol, the Km for OATP1A2 is 84 μM.(In Vivo):In male OF1 mice bearing B16F10 tumor cells, blocking the neuroendocrine response through the administration of Nadolol (20 mg/kg) results in fewer and smaller pulmonary metastatic foci in subjects exposed to acute social stress.

Key Properties

• CAS Number: 42200-33-9
• MW: 309.4
• Purity: >98% (HPLC)
• Formula: C₁₇H₂₇NO₄
• SMILES: O[C@@H]1CC2=C(C(OCC(O)CNC(C)(C)C)=CC=C2)C[C@@H]1O
• Target: Adrenergic Receptor
• Solubility: soluble in Water

Bioactivity

• In Vivo:
  In male OF1 mice bearing B16F10 tumor cells, blocking the neuroendocrine response through the administration of Nadolol (20 mg/kg) results in fewer and smaller pulmonary metastatic foci in subjects exposed to acute social stress.
• In Vitro:
  In human embryonic kidney 293 cells, (-)-Epigallocatechin gallate (EGCG) competitively inhibits OATP1A2-mediated uptake of Nadolol with a Ki value of 19.4 μM. With respect to Nadolol, the Km for OATP1A2 is 84 μM.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Nadolol, Corgard, Solgol, SQ-11725, Anabet

Quick Database Links

Gene Symbol

Adrenergic Receptor