Nadifloxacin

SKU: orb1308551

Description

Nadifloxacin (OPC7251) is a topical fluoroquinolone antibiotic investigated for the treatment of Acne Vulgaris. Research applications include in vitro studies against Cutibacterium acnes and in vivo clinical trials assessing its efficacy in reducing inflammatory lesions.

Research Area

Cell Biology, Immunology & Inflammation, Infectious Disease & Virology, Molecular Biology

Key Properties

• CAS Number: 124858-35-1
• MW: 360.38
• Purity: 100.00%
• Formula: C₁₉H₂₁FN₂O₄
• SMILES: O=C1C=2C3=C(C(=C(F)C2)N4CCC(O)CC4)CCC(C)N3C=C1C(O)=O
• Target: Interleukin,DNA/RNA Synthesis,Antibacterial,Antibiotic
• Solubility: Ethanol:< 1 mg/mL (insoluble or slightly soluble);H2O:< 1 mg/mL (insoluble or slightly soluble);DMSO:3.85 mg/mL (10.68 mM)

Bioactivity

• In Vitro:
  Nadifloxacin is a potent, broad-spectrum, quinolone agent approved for topical use in acne vulgaris and skin infections. Nadifloxacin inhibits the enzyme DNA gyrase that is involved in bacterial DNA synthesis and replication, thus inhibiting the bacterial multiplication. In vitro studies of nadifloxacin show potent and broad-spectrum antibacterial activity against aerobic Gram-positive, Gram-negative and anaerobic bacteria. Additionally, studies also suggest that the effectiveness of nadifloxacin in inflammatory acne lesions may be attributed to its inhibitory effect on pro-inflammatory cytokines like interleukin (IL)-1α, IL-6, and IL-8 which also play an important role in acne pathogenesis.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Bacterial, Antibiotic, Inhibitor, inhibit, Nadifloxacin, OPC 7251, OPC7251, OPC-7251

Compound Identifiers

PubChem CID

4410