N6-(2-Hydroxyethyl)adenosine

SKU: orb1741474

Description

N6-(2-Hydroxyethyl)adenosine is a small molecule exhibiting calcium channel blocking and anti-inflammatory properties. It is utilized in research to study cerebrovascular and coronary circulation regulation, with in vitro and in vivo studies suggesting potential sedative effects.

Research Area

Cell Biology, Immunology & Inflammation, Metabolism Research, Molecular Biology, Pharmacology & Drug Discovery, Signal Transduction, Stem Cell & Developmental Biology

Key Properties

• CAS Number: 4338-48-1
• MW: 311.29
• Purity: 99.40% (May vary between batches)
• Formula: C₁₂H₁₇N₅O₅
• SMILES: OCCNc1ncnc2n(cnc12)[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O
• Target: Mitochondrial Metabolism,ROS,NF-κB,Apoptosis,Nucleoside Antimetabolite/Analog,TGF-beta/Smad,Autophagy,Calcium Channel
• Solubility: DMSO:4.8 mg/mL (15.42 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:1 mg/mL (3.21 mM)

Bioactivity

• In Vivo:
  Injury of Kidney Tissue in UUO Mice Ameliorated by Intraperitoneal Administration of N6-(2-Hydroxyethyl) adenosine (2.5, 5, and 7.5 mg/kg; intraperitoneal injection). N6-(2-Hydroxyethyl) adenosine treatment prevents the accumulation of fibrosis-related proteins (TGF-β1, α-SMA, collagen I, and Fibronectin) and inflammatory cytokines (TNF-α, IL-6, IL-1β, and IL-10) associated with renal interstitial fibrosis. N6-(2-Hydroxyethyl) adenosine could block the accumulation of M1 macrophages, and induced the accumulation of M2 macrophages in ligated kidneys .
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• In Vitro:
  N6-(2-Hydroxyethyl)adenosine can suppress TGF-β1 or LPS-induced TGF-β1/Smad and NF-κB signaling pathways in vitro. The levels of ECM production, indicated by expression of collagen I, α-SMA and Fibronectin, are significantly reduced by treatment with N6-(2-Hydroxyethyl)adenosine dose-dependently (5, 10, and 20 μg/ml). Similarly, TGF-β and LPS stimulate increased levels of TNF-α, IL-1β and IL-10. N6-(2-Hydroxyethyl)adenosine treatment reduces the elevated levels of TNF-α and IL-1β and increases IL-10 secretion dose-dependently .
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Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Ca(2+) receptor, Calcium Channel, CalciumChannel

Compound Identifiers

PubChem CID

96124