n-Butylidenephthalide

SKU: orb1222058

Description

Butylidenephthalide is an inhibitor of platelet-derived growth factor (PDGF). Butylidenephthalide activity leads to the reduction of liver fibrosis, increased Nur77 (NR4A1) expression, and downregulation of EMT-related genes such as Snail (Snail/SNAI1) and Slug (Slug/SNAI2).

Key Properties

• CAS Number: 551-08-6
• MW: 188.22
• Purity: >98% (HPLC)
• Formula: C₁₂H₁₂O₂
• SMILES: CCCC=C1C2=CC=CC=C2C(=O)O1
• Target: TRP/TRPV Channel
• Solubility: In Vitro: DMSO : 250 mg/mL (1328.23 mM)

Bioactivity

• In Vitro:
  3-Butylidenephthalide (Butylidenephthalide) abrogates the myofibroblasts activation and mesenchymal transdifferentiation in oral submucous fibrosis.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Butylidenephthalide | BP | 3-Butylidene Phthalide

Quick Database Links

Gene Symbol

TRP/TRPV Channel