Mulberrofuran C

SKU: orb1682079

Description

Mulberrofuran C, a bioactive benzofuran from Morus alba, exhibits anti-Alzheimer's potential by inhibiting Aβ₁₋₄₂ and tau aggregation, AChE activity, and oxidative stress. It demonstrates neuroprotective effects in cellular models, making it a candidate for research in neurodegenerative disease mechanisms and therapeutic development.

Research Area

Metabolism Research, Neuroscience, Protein Biochemistry, Signal Transduction, Stem Cell & Developmental Biology

Key Properties

• CAS Number: 77996-04-4
• MW: 580.58
• Purity: 99.13%
• Formula: C₃₄H₂₈O₉
• SMILES: C(=O)([C@@H]1[C@@H](C=C(C)C[C@H]1C2=C(O)C=C(O)C=C2)C3=C(O)C=C(C=C3O)C4=CC=5C(O4)=CC(O)=CC5)C6=C(O)C=C(O)C=C6
• Target: Cholinesterase (ChE),Gamma-secretase,Antioxidant,Microtubule Associated

Bioactivity

• Target IC50:
  HSV1 (standard strain, Vero cells):5.0 μg/mL|HSV1 (clinical strain, Vero cells):3.1 μg/mL|HSV2 (Vero cells):3.2 μg/mL|NO production (LPS-induced BV2 microglial cells):21.8 μM|AChE:4.2 μM
• In Vitro:
  Mulberrofuran C (Compound 2) exhibited multi-target in vitro activities relevant to Alzheimer’s disease. At 20 μM, Mulberrofuran C inhibited Aβ₁₋₄₂ self-aggregation by 70.7%, comparable to resveratrol (72.8%) and stronger than methylene blue (33.5%). Mulberrofuran C also suppressed tau protein aggregation (49.1% inhibition) and demonstrated strong antioxidant activity (ORAC value: 2.9, higher than Trolox). In cholinesterase inhibition assays, Mulberrofuran C showed moderate AChE inhibition (IC₅₀ = 4.2 μM), and in LPS-induced BV2 microglial cells, Mulberrofuran C suppressed NO production with an IC₅₀ of 21.8 μM . Mulberrofuran C (Compound 2) exhibited in vitro antiviral activity against herpes simplex viruses HSV-1 and HSV-2 in Vero cells. In plaque reduction assays, Mulberrofuran C showed IC₅₀ values of 5.0, 3.1, and 3.2 μg/mL against HSV-1 (standard strain), HSV-1 (clinical strain), and HSV-2, respectively. The cytotoxic concentration (CC₅₀) of Mulberrofuran C was 28.0 μg/mL, yielding selectivity indices between 5.6 and 8.9, indicating moderate antiviral efficacy with acceptable cytotoxicity.

Storage & Handling

• Storage: keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

HSV

Compound Identifiers

PubChem CID

157143