MTX115325

SKU: orb2565748

Description

MTX115325 is a potent, orally bioavailable, and brain-penetrant USP30 inhibitor (IC₅₀=12 nM) that induces mitophagy by enhancing TOM20 ubiquitination (EC₅₀=32 nM). It demonstrates neuroprotective efficacy in research models, preventing dopaminergic neuron loss and preserving striatal dopamine levels in vivo.

Research Area

Cell Biology, Molecular Biology, Protein Biochemistry

Key Properties

• CAS Number: 2750895-97-5
• MW: 348.36
• Formula: C₁₈H₁₆N₆O₂
• SMILES: C(=O)(N1[C@@]2([C@@]([C@@H](C)N(C#N)C2)(CC1)[H])[H])C=3OC(=CN3)C=4C=C(C#N)N=CC4
• Target: DUB,Mitophagy

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

162385067