MS98

SKU: orb1690955

Description

MS98 is a potent and selective PROTAC that induces degradation of total AKT (pan-AKT1/2/3) with a DC50 of 78 nM, exhibiting high-affinity binding to AKT isoforms. This degrader is a valuable chemical tool for probing AKT-dependent signaling in cancer research, applicable in both cellular and in vivo models to study oncogenesis and therapeutic resistance.

Research Area

Pharmacology & Drug Discovery, Signal Transduction

Key Properties

• CAS Number: 2376137-31-2
• MW: 1097.86
• Formula: C₅₈H₈₁ClN₁₀O₇S
• SMILES: C[C@H](NC(=O)[C@@H]1C[C@@H](O)CN1C(=O)[C@@H](NC(=O)CCCCCCCCCCC(=O)NCCNC[C@@H](C(=O)N1CCN(CC1)c1ncnc2[C@H](O)C[C@@H](C)c12)c1ccc(Cl)cc1)C(C)(C)C)c1ccc(cc1)-c1scnc1C
• Target: Others,Akt,PROTACs

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

155432174