MPP+-d3 iodide

SKU: orb3138151

Description

MPP+-d3 (iodide) is the deuterated variant of MPP+ (iodide). MPP+ iodide is a toxic metabolite of the neurotoxin MPTP, which induces Parkinsonian symptoms in animal models by selectively destroying dopaminergic neurons in the substantia nigra. It is absorbed into dopaminergic neurons via the dopamine transporter and exerts its neurotoxic effects by interfering with mitochondrial respiratory chain complex I. Additionally, MPP+ iodide is a high-affinity substrate for the serotonin transporter (SERT).

Key Properties

• CAS Number: 207556-07-8
• MW: 300.15
• Formula: C₁₂H₁₂IN
• SMILES: C([N+]=1C=CC(=CC1)C2=CC=CC=C2)([2H])([2H])[2H].[I-]
• Target: Mitochondrial Metabolism

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

Mitochondrial Metabolism