Moxalactam Disodium

SKU: orb1221917

Description

Moxalactam sodium salt is an antibiotic compound more effective against Escherichia coli and Pseudomonas aeruginosathan cephalosporins.(In Vitro):Moxalactam (Latamoxef) inhibits 90% of strains of Escherichia coli, Klebsiella species, Proteus species, Morganella morganii, Neisseria gonorrhoeae, Neisseria meningitidis, Haemophilus influenzae and Salmonella species, including strains which are resistant to Cephalothin (HY-B1275A) and Gentamicin (HY-A0276A) at concentrations of less than 1 μg/mL.Moxalactam exhibits moderate activity against P. aeruginosa and is usually active against other species of Pseudomonas, Acinetobacter species are usually resistant to Moxalactam.Moxalactam has marked stability in vitro against a variety of β-lactamases, including that produced by B. fragilis, inhibits production of β-lactamases and does not induce class I β-lactamase.(In Vivo):Moxalactam (Latamoxef) (0-7.4 mg/mouse; s.c.; once) is effective against bacterial infections in mice.

Key Properties

• CAS Number: 64953-12-4
• MW: 564.44
• Purity: >98% (HPLC)
• Formula: C₂₀H₁₈N₆Na₂O₉S
• SMILES: [H][C@]12OCC(CSC3=NN=NN3C)=C(N1C(=O)[C@]2(NC(=O)[C@H](C(=O)O[Na])C1=CC=C(O)C=C1)OC)C(=O)O[Na]
• Target: AChR
• Solubility: DMSO : ≥ 38 mg/mL; 67.32 mM

Bioactivity

• In Vivo:
  Moxalactam (Latamoxef) (0-7.4 mg/mouse; s. c. ; once) is effective against bacterial infections in mice. Animal model: Four-week-old male strain ICR mice, weighing 18-20 g, bacterial infection model. Dosage: 0-7.4 mg/mouse. Administration: Subcutaneous injection, once. Result: Showed protective activity with ED50s less than 7.4 mg/mouse against gram-positive and gram-negative bacteria infected mice.
• In Vitro:
  Moxalactam (Latamoxef) inhibits 90% of strains of Escherichia coli, Klebsiella species, Proteus species, Morganella morganii, Neisseria gonorrhoeae, Neisseria meningitidis, Haemophilus influenzae and Salmonella species, including strains which are resistant to Cephalothin (HY-B1275A) and Gentamicin (HY-A0276A) at concentrations of less than 1 μg/mL. Moxalactam exhibits moderate activity against P. aeruginosa and is usually active against other species of Pseudomonas, Acinetobacter species are usually resistant to Moxalactam. Moxalactam has marked stability in vitro against a variety of β-lactamases, including that produced by B. fragilis, inhibits production of β-lactamases and does not induce class I β-lactamase.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Moxalactam Disodium | Latamoxef, Sodium Salt

Quick Database Links

Gene Symbol

AChR