Monomethyl fumarate

SKU: orb1940785

Description

Monomethyl fumarate is a potent agonist of GPR109A .(In Vitro):Monomethyl fumarate (25 μM; 24 hours) attenuates 7β-OHC-induced cytotoxicity: cell growth inhibition; decreased cell viability; mitochondrial dysfunction; and cell death induction.

Key Properties

• CAS Number: 2756-87-8
• MW: 130.099
• Purity: >98% (HPLC)
• Formula: C₅H₆O₄
• SMILES: COC(=O)\C=C\C(O)=O
• Target: GPR
• Solubility: In Vitro: DMSO : 50 mg/mL (384.32 mM)

Bioactivity

• In Vivo:
  A single dose of Monomethyl fumarate (50-100 mg/kg; IP) before light exposure prevents these morphologic changes (bright light exposure induced photoreceptor death) in a dose-dependent manner. Monomethyl fumarate (100 mg/kg) reduces retinal inflammation and oxidative stress. Monomethyl fumarate significantly suppresses light-induced retinopathy (LIR) upregulated genes in the NFkB pathway including: Nlrp3, Casp1, Il-1β, and Tnf-α. Animal model: Albino BALB/c mice (male, 6 weeks old). Dosage: 50, 65, 75, 100 mg/kg. Administration: IP. Result: Prevented these morphologic changes (bright light exposure induced photoreceptor death) in a dose-dependent manner.
• In Vitro:
  Monomethyl fumarate completely inhibits forskolin induced cAMP synthesis with an IC50 of 70 nM. Monomethyl fumarate induces a dose-dependent Ca2+ signal in GPR109A transfected cells with an EC50 of 9.4 μM. Monomethyl fumarate (25 μM; 24 hours) attenuates 7β-OHC-induced cytotoxicity: cell growth inhibition; decreased cell viability; mitochondrial dysfunction; and cell death induction.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

GPR