Mogroside V

SKU: orb1221681

Description

Mogroside V is a widely used sweetener, has in vitro AMPK activating effect, it also has anti-inflammatory potential in murine macrophages and a murine ear edema model, and has the potential to protect against LPS-induced airway inflammation in a model of ALI. Mogroside V has antioxidant properties and possesses tumor growth inhibitory activity in pancreatic cancer models.

Key Properties

• CAS Number: 88901-36-4
• MW: 1287.43
• Purity: >98% (HPLC)
• Formula: C₆₀H₁₀₂O₂₉
• SMILES: [C@@H]12[C@]([C@H]3C(=CC2)C([C@H](CC3)O[C@@H]2O[C@H](CO[C@@H]3O[C@@H]([C@H]([C@@H]([C@H]3O)O)O)CO)[C@H]([C@@H]([C@H]2O)O)O)(C)C)([C@@H](C[C@]2([C@]1(CC[C@@H]2[C@@H](CC[C@@H](O[C@H]1[C@H](O[C@@H]2O[C@@H]([C@H]([C@@H]([C@H]2O)O)O)CO)[C@H]([C@@H]([C@H](O1)CO[C@@H]1O[C@@H]([C@H]([C@@H]([C@H]1O)O)O)CO)O)O)C(C)(C)O)C)C)C)O)C
• Target: TRP/TRPV Channel
• Solubility: In Vitro: DMSO : 100 mg/mL (77.67 mM)

Bioactivity

• In Vivo:
  Animal model: T2D model rats. Dosage: 100 mg/kg. Administration: Oral gavage (p.o.). Result: Detected 28 metabolites of mogroside V compared to the blank biological samples. Displayed larger peak areas of metabolites in T2D rat plasma samples than those in healthy sample.
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• In Vitro:
  Immunofluorescence Cell line: IVM oocytes. Concentration: 20 μM. Incubation time: 40 h. Result: Increased the fluorescence intensity compared to control group. Increased the red/green fluorescence intensity ratio compared to control group. Real Time qPCR Cell line: IVM oocytes. Concentration: 20 μM. Incubation time: 40 h. Result: Increased the relative mRNA expression of SOD, CAT, PGC-1α and TFAM than in control group. Cell Viability Assay Cell line: PANC-1 cells. Concentration: 1-250 μM. Incubation time: 24 h. Result: Increased the percentage of TUNEL-positive cells ranging from 2.91% to 92.25%. Apoptosis Analysis Cell line: PANC-1 cells. Concentration: 1-250 μM. Incubation time: 24 h. Result: Induced apoptosis in PANC-1 cells in a concentration- and time-dependent manner Western blot analysis. Cell line: PANC-1 cells. Concentration: 0-250 μM. Incubation time: 24 h. Result: Increased the expression of the cyclin kinase inhibitors CDKN1A (p21WAF1) and CDKN1B (p27) in a dose-dependent manner. Decreased the the expression of the pro-proliferative cell cycle regulators CCND1 (cyclin D1), CCNE1 (cyclin E1) and CDK2.Suppressed phosphorylation of the kinases upstream of STAT3, including that of JAK2 and TYK2.
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Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

TRP/TRPV Channel