MMPIP hydrochloride

SKU: orb1305748

Description

MMPIP hydrochloride is a selective allosteric antagonist of the metabotropic glutamate receptor 7 (mGluR7). It is a valuable research tool for investigating the receptor's role in CNS functions, including anxiety, learning, and nociception, in both in vitro and in vivo experimental models.

Research Area

Neuroscience

Key Properties

• CAS Number: 1215566-78-1
• MW: 369.8
• Purity: 99.88% (May vary between batches)
• Formula: C₁₉H₁₆ClN₃O₃
• SMILES: Cl.COc1ccc(cc1)-c1cc2onc(-c3ccncc3)c2c(=O)n1C
• Target: GluR
• Solubility: DMSO:3.7 mg/mL (10.01 mM)

Bioactivity

• In Vivo:
  MMPIP hydrochloride alleviates pain and normalizes affective and cognitive behavior in neuropathic mice. MMPIP hydrochloride (10 mg/kg; i.p.) rescues the MK-801 (0.1 mg/kg)-induced cognitive impairments, by improving the choice accuracy. MMPIP hydrochloride (10 mg/kg) attenuates the amplitude of the acoustic startle response and markedly enhances the prepulse-induced inhibition of the acoustic startle response (up to 137% of control).
• In Vitro:
  In CHO cells coexpressing rat mGluR7 with Gα15, MMPIP hydrochloride inhibits L-(+)-2-amino-4-phosphonobutyric acid (L-AP4; 0.5 mM)-induced intracellular Ca2+ mobilization with an IC50 of 26 nM. MMPIP hydrochloride also antagonizes L-AP4-induced inhibition of cAMP accumulation with an IC50 of 610 nM. MMPIP hydrochloride inhibits L-AP4-induced inhibition of forskolin-stimulated cAMP accumulation in CHO cells expressing rat mGluR7.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

system, glutamate, Inhibitor, Metabotropic glutamate receptors, metabotropic, mGluR, mGlu7, mGluR7, MMPIP, MMPIP Hydrochloride, MMPIP hydrochloride, MMPIP hydrochloride (479077-02-6 Free base), nervous, neuropathic, inhibit, pain, allosteric, 479077-02-6, 479077-02-6 Free base, behavior, cognitive, central

Compound Identifiers

PubChem CID

52974245