MLS1082

SKU: orb1690178

Description

MLS1082 is a pyrimidinone-derived positive allosteric modulator of the dopamine D1 receptor (D1R). It potentiates G-protein signaling upon dopamine binding, showing research utility for studying D1R neurobiology in models of Parkinson's disease and related neurodegenerative disorders.

Research Area

Neuroscience, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 883958-36-9
• MW: 385.46
• Purity: 99.53%
• Formula: C₂₄H₂₃N₃O₂
• SMILES: O=C1C=2C=CC=CC2N(C=3N=C(N(C=4C=CC=CC4)C(=O)C13)C5CCCCC5)C
• Target: Dopamine Receptor
• Solubility: DMSO:8 mg/mL (20.75 mM)

Bioactivity

• In Vitro:
  MLS1082 enhances β-Arrestin and G protein-mediated D1R signaling .

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

MLS 1082, MLS1082, MLS-1082

Compound Identifiers

PubChem CID

2030130