MLS0315771

SKU: orb1308020

Description

MLS0315771 is a potent and selective competitive inhibitor of phosphomannose isomerase (MPI), exhibiting an IC50 of approximately 1 µM and a Ki of 1.4 µM. This small molecule is a valuable research tool for studying congenital disorders of glycosylation (CDG) and MPI's role in metabolism, enabling both in vitro enzymatic assays and cellular research.

Key Properties

• CAS Number: 727664-91-7
• MW: 273.33
• Purity: 98.92% (May vary between batches)
• Formula: C₁₅H₁₂FNOS
• SMILES: Cc1ccc(C)c(c1)-n1sc2cc(F)ccc2c1=O
• Target: Others
• Solubility: DMSO:11 mg/mL (40.24 mM)

Bioactivity

• Target IC50:
  MPI:1 μM (IC50)
• In Vitro:
  MLS0315771 is toxic to the zebrafish embryos above 2 μM. MLS0315771 toxicity at higher concentrations is an off-target effect. MLS0315771 enhances mannose flux toward glycosylation. It ~50% of embryos appeared sick within 20 min at 8-10 μM, and most of them die by 30-60 min.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Inhibitor, inhibit, MPI, MLS0315771, MLS-0315771, MLS 0315771

Compound Identifiers

PubChem CID

1510389