MLi-2

SKU: orb1308022

Description

MLi-2 is a brain-penetrant, highly selective LRRK2 kinase inhibitor with sub-nanomolar potency in biochemical, cellular binding, and phospho-Ser935 dephosphorylation assays. This tool compound is widely used in Parkinson's disease research for investigating LRRK2 biology and pathogenesis in both in vitro and in vivo models.

Research Area

Cell Biology

Key Properties

• CAS Number: 1627091-47-7
• MW: 379.46
• Purity: 99.33%
• Formula: C₂₁H₂₅N₅O₂
• SMILES: C[C@H]1CN(C[C@@H](C)O1)c1cc(ncn1)-c1n[nH]c2ccc(OC3(C)CC3)cc12
• Target: LRRK2
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (5.27 mM);DMSO:60 mg/mL (158.12 mM)

Bioactivity

• Target IC50:
  LRRK2:0.76 nM
• In Vivo:
  MLi-2, a structurally novel, highly potent, and selective LRRK2 kinase inhibitor with central nervous system activity. MLi-2 exhibits exceptional potency in a purified LRRK2 kinase assay in vitro (IC50 = 0.76 nM), a cellular assay monitoring dephosphorylation of LRRK2 pSer935 LRRK2 (IC50 = 1.4 nM), and a radioligand competition binding assay (IC50 = 3.4 nM). MLi-2 has greater than 295-fold selectivity for over 300 kinases in addition to a diverse panel of receptors and ion channels.
• In Vitro:
  MLi-2, a structurally novel, highly potent, and selective LRRK2 kinase inhibitor with central nervous system activity. MLi-2 exhibits exceptional potency in a purified LRRK2 kinase assay in vitro (IC50 = 0.76 nM), a cellular assay monitoring dephosphorylation of LRRK2 pSer935 LRRK2 (IC50 = 1.4 nM), and a radioligand competition binding assay (IC50 = 3.4 nM). MLi-2 has greater than 295-fold selectivity for over 300 kinases in addition to a diverse panel of receptors and ion channels.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

disease, Leucine-rich repeat kinase 2, Parkinson's, LRRK2, orally, MLi 2, MLi2, MLi-2, Inhibitor, inhibit

Compound Identifiers

PubChem CID

78319901