ML372

SKU: orb1699928

Description

ML372 is a potent and selective small molecule SMN2 splicing modulator, exhibiting an EC50 of 12 nM and increasing SMN protein levels by 325%. It demonstrates favorable pharmacokinetics, blood-brain barrier penetration, and tolerability, supporting its use in preclinical research for spinal muscular atrophy (SMA) in both cellular and animal models.

Research Area

Cell Biology, Molecular Biology

Key Properties

• CAS Number: 1331745-61-9
• MW: 360.43
• Formula: C₁₈H₂₀N₂O₄S
• SMILES: OC(=O)C1CCN(CC1)c1ncc(s1)-c1ccc2OCCCOc2c1
• Target: DNA/RNA Synthesis,Others

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

46907666