ML-193

SKU: orb1306094

Description

ML-193

Research Area

Pharmacology & Drug Discovery

Key Properties

• CAS Number: 713121-80-3
• MW: 527.59
• Purity: 99.79%
• Formula: C₂₈H₂₅N₅O₄S
• SMILES: Cc1noc(NS(=O)(=O)c2ccc(NC(=O)c3cc(nc4c(C)cc(C)cc34)-c3ccccn3)cc2)c1C
• Target: Cannabinoid Receptor
• Solubility: DMSO:60 mg/mL (113.72 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (3.79 mM)

Bioactivity

• Target IC50:
  GPR55:221 nM
• In Vivo:
  Intra-striatal administration of ML193 increased time on the rotarod, decreased latency to remove the label and slip steps in 6-OHDA-lesioned rats mostly at the dose of 1 g/rat.
• In Vitro:
  ML193, a selective GPR55 antagonist. ML184 significantly promoted neuronal differentiation in vitro while ML193 reduced differentiation rates as compared to vehicle treatment.Continuous administration of O-1602 into the hippocampus via a cannula connected to an osmotic pump resulted in increased Ki67+ cells within the dentate gyrus. O-1602 increased immature neuron generation, as assessed by DCX+ and BrdU+ cells, as compared to vehicle-treated animals. GPR55-/- animals displayed reduced rates of proliferation and neurogenesis within the hippocampus while O-1602 had no effect as compared to vehicle controls.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

CannabinoidReceptor, Cannabinoid Receptor, CID 1261822, CID1261822, CID-1261822, deficits, disease, ML193, ML-193, ML 193, Parkinson, motor, inhibit, Inhibitor, GPR55, G protein-coupled receptor 55, sensorimotor

Compound Identifiers

PubChem CID

1261822