MK-8745

SKU: orb1305435

Description

MK-8745

Research Area

Cell Biology, Epigenetics & Chromatin

Key Properties

• CAS Number: 885325-71-3
• MW: 431.91
• Purity: 99.79%
• Formula: C₂₀H₁₉ClFN₅OS
• SMILES: Fc1c(Cl)cccc1C(=O)N1CCN(Cc2cccc(Nc3nccs3)n2)CC1
• Target: Aurora Kinase,Apoptosis
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (4.63 mM);Ethanol:1 mg/mL (2.32 mM);H2O:< 1 mg/mL (insoluble or slightly soluble);DMSO:55 mg/mL (127.34 mM)

Bioactivity

• Target IC50:
  Aurora A:0.6 nM
• In Vivo:
  MK-8745 induces apoptosis in a p53-dependent manner across various cell lines in vitro. Exposure of p53 wild-type cells to MK-8745 leads to the induction of p53 phosphorylation (ser15) and an increase in p53 protein expression. This p53-dependent apoptotic effect of MK-8745 is further confirmed in HCT 116 p53 (-/-) cells transfected with wild-type p53. In non-Hodgkin's lymphoma cell lines, MK-8745 causes cell cycle arrest at the G2/M phase with the accumulation of tetraploid nuclei, followed by cell death. Treatment with MK-8745 induces p21 (waf1/cip1) and CycB1, indicating cell cycle arrest and an increased population of cells in the G2/M phase. Additionally, MK-8745 treatment leads to the rapid degradation of Aurora-A substrates (TACC3, Eg5, and TPX2) following the reduction of phospho-Aurora-A.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

MK 8745, MK8745, MK-8745, inhibit, Inhibitor, AuroraKinase, Aurora A, Aurora Kinase, Aurora B, Apoptosis

Compound Identifiers

PubChem CID

11676373