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MK-3697

SKU: orb1226752

Description

MK-3697 is a potent, selective, orally bioavailable Orexin 2 receptor (OX2R) antagonist with Ki of 1.1 nM and IC50 of 16 nM, shows exquisite selectivity over OX1R (Ki=18 uM); MK-3697 is orally efficacious in sleep experiments across species with high OX2R occupancy and low OX1R blockade, demonstrated excellent sleep efficacy across species, and shows potential for the treatment of insomnia.Sleep Disorder Phase 2 Discontinued.

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Key Properties

CAS Number1224846-01-8
MW447.5096
Purity>98% (HPLC)
FormulaC23H21N5O3S
SMILESCOC1=C(OC)N=C(CNC(=O)C2=CC(=NC=C2C2=NC=CS2)C2=CC(C)=CN=C2)C=C1
TargetOrexin Receptor
SolubilityDMSO: 22.5 mg/mL

Storage & Handling

StorageStorage temperature: -20°C. Stability: ≥ 2 years
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

MK 3697 | MK3697

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    1224846-01-8

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    5 mg, 10 mg, 25 mg, 50 mg, 1 ml x 10 mM (in DMSO), 100 mg, 1 mg, 2 mg
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Protocol Information

MK-3697 (orb1226752)

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Available Sizes

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200 mg
500 mg
2 mg
$ 110.00
5 mg
$ 160.00
10 mg
$ 190.00
25 mg
$ 320.00
50 mg
$ 500.00
100 mg
$ 710.00