MK-1064

SKU: orb1303845

Description

MK-1064 (Urokinase inhibitor 1) is a potent and selective orexin 2 receptor antagonist (2-SORA). This compound is a valuable research tool for investigating sleep-wake regulation and is utilized in both in vitro binding assays and in vivo models of insomnia.

Research Area

Neuroscience, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 1207253-08-4
• MW: 461.9
• Purity: 99.88%
• Formula: C₂₄H₂₀ClN₅O₃
• SMILES: COc1ccc(CNC(=O)c2cc(cnc2-c2ccccn2)-c2cncc(Cl)c2)nc1OC
• Target: OX Receptor
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (4.33 mM);H2O:< 0.1 mg/mL (insoluble);DMSO:50 mg/mL (108.25 mM)

Bioactivity

• Target IC50:
  OX2 receptor:18 nM|OX2 receptor:0.5 nM (Ki)|OX1 receptor:1789 nM|OX1 receptor:1584 nM (Ki)

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

stress, Sleep, OXReceptor, Urokinase inhibitor 1, Hypocretin Receptor, Inhibitor, HCRT Receptor, insomnia, MK1064, MK-1064, MK 1064, OX2, OX Receptor, OX2R knockout, Orexin Receptor (OX Receptor), inhibit

Compound Identifiers

PubChem CID

44633765