Mirikizumab Antibody

SKU: orb1980360

Description

Mirikizumab is a humanized monoclonal antibody that selectively inhibits the p19 subunit of interleukin-23 (IL-23), blocking its receptor interaction. It is utilized in preclinical and clinical research, including in vitro binding assays and in vivo models, for investigating immune-mediated diseases such as ulcerative colitis.

Research Area

Immunology & Inflammation

Key Properties

• CAS Number: 1884201-71-1
• MW: 144.26 kDa
• Purity: 98.41% (SEC-HPLC)
• Target: IL Receptor,Interleukin

Bioactivity

• In Vivo:
  Mirikizumab (4.4 pm-800 nM, 48 h) completely neutralizes IL-17A induced by human and cynocytic monkey IL-23 in mouse spleen cells with IC50 of 82 pM and 120 pM, respectively.
• In Vitro:
  Mirikizumab binds IL-23 in humans and monkeys with high affinity, with Kd values of 21 pM and 55 pM, respectively.

Storage & Handling

• Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

LY3074828, LY 3074828

Quick Database Links

Gene Symbol

IL Receptor,Interleukin