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Mildronate

SKU: orb1224050

Description

Mildronate is an inhibitor of biosynthesis of L-carnitine by gamma-butyrobetaine (GBB) hydroxylase and as a competitive inhibitor of renal carnitine reabsorption.

Images & Validation

Key Properties

CAS Number76144-81-5
MW146.19
Purity>98% (HPLC)
FormulaC6H14N2O2
SMILESO=C([O-])CCN[N+](C)(C)C
TargetHydroxylase
SolubilitySoluble in Water

Bioactivity

In Vitro
RT-PCR Cell line: Rat alveolar type II epithelial RLE-6TN cells in hypoxia incubator. Concentration: 20, or 40 μM. Incubation time: 24 h. Result: Significantly decreased the mRNA expression of PFKP, PDK1, and PKM2 compared with the hypoxia group. Western blot analysis. Cell line: Rat alveolar type II epithelial RLE-6TN cells in hypoxia incubator. Concentration: 20, or 40 μM. Incubation time: 24 h. Result: Significantly reduced the protein expression of PFKP, PKM2, and LDHA.

Storage & Handling

StorageStorage temperature: -20°C. Stability: ≥ 2 years
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

Meldonium | Kvaterin | Mildronate | Quaterin

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Mildronate (orb1224050)

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