Migalastat hydrochloride

SKU: orb2901784

Description

Migalastat hydrochloride (GR181413A) is a potent and competitive inhibitor of α-galactosidase A (α-Gal A) with an IC50 of 0.04 μM for human α-Gal A.

Key Properties

• CAS Number: 75172-81-5
• MW: 199.63
• Purity: >98% (HPLC)
• Formula: C₆H₁₄ClNO₄
• SMILES: Cl.OC[C@H]1NC[C@H](O)[C@@H](O)[C@H]1O
• Solubility: In Vitro: H2O : ≥ 200 mg/mL (1001.85 mM)

Bioactivity

• In Vivo:
  Animal model: Male nontransgenic (Non-Tg) C57BL/6 mice; transgenic mice expressing human mutant R301Q α-Gal A (TgM), α-Gal A knockout mice (KO), mice express human R301Q α-Gal A in a null background (TgM/KO). Dosage: 3 mg/kg. Administration: Oral gavage; every day for 4 weeks. Result: Reduced Globotriaosylceramide (Gb3) storage remarkably in kidney of mice.
• In Vitro:
  Cell Viability Assay Cell line: EHK cells mutated α-Gal A. Concentration: 10 μM. Incubation time: 9 days. Result: Reduced Gb3 accumulation and lysosome volume.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only