Mifepristone (RU486)

SKU: orb3032958

Description

Mifepristone (RU-486) is a potent steroidal antagonist exhibiting subnanomolar affinity for progesterone receptors (PR IC₅₀ = 0.2 nM) and nanomolar activity against glucocorticoid receptors (GR IC₅₀ = 2.6 nM). This dual-receptor modulator competitively blocks endogenous hormone binding while inducing distinct conformational changes that prevent coactivator recruitment, demonstrating differential antagonism between PR and GR signaling pathways.

Key Properties

• CAS Number: 84371-65-3
• MW: 429.593708276749
• Purity: >98%
• Formula: C₂₉H₃₅NO₂
• SMILES: C[C@@]12[C@](O)(C#CC)CC[C@H]1[C@@H]1CCC3=CC(CCC3=C1[C@@H](C1C=CC(N(C)C)=CC=1)C2)=O

Storage & Handling

• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only