MF-094

SKU: orb1309426

Description

MF-094 is a potent and selective USP30 inhibitor (IC50 = 0.12 µM) that enhances protein ubiquitination and promotes mitophagy. This small molecule is a valuable research tool for studying mitochondrial quality control, Parkinson's disease pathways, and autophagy mechanisms in both cellular and animal models.

Research Area

Cell Biology, Molecular Biology, Protein Biochemistry

Key Properties

• CAS Number: 2241025-68-1
• MW: 535.7
• Purity: 98.46% (May vary between batches)
• Formula: C₃₀H₃₇N₃O₄S
• SMILES: CC(C)(C)NS(=O)(=O)c1cccc2c(NC(=O)[C@H](Cc3ccccc3)NC(=O)C3CCCCC3)cccc12
• Target: DUB
• Solubility: DMSO:150 mg/mL (280.01 mM)

Bioactivity

• Target IC50:
  USP30:120 nM
• In Vivo:
  Subcutaneous injection of MF-094 can promote the ubiquitination level of FUNDC1. MF-094 can significantly reduce the increase in systolic blood pressure and urine protein in PE mice.
  Read more...
• In Vitro:
  In hypoxic trophoblast cells supplemented with MF-094, GSH and SOD levels increased, while MDA levels decreased.

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Deubiquitinase, DUBs, inhibit, MF 094, MF094, MF-094, Inhibitor, USP30

Compound Identifiers

PubChem CID

138319686