Methyl-Hesperidin

SKU: orb1310813

Description

Methyl Hesperidin is a citrus-derived flavonoid, specifically a flavanone glycoside (C28H34O15), whose aglycone is hesperetin. It is widely used in research to investigate antioxidant, anti-inflammatory, and vascular-protective mechanisms in both in vitro and in vivo experimental models.

Research Area

Epigenetics & Chromatin, Signal Transduction

Key Properties

• CAS Number: 11013-97-1
• MW: 624.5871
• Purity: 98.51% (May vary between batches)
• Formula: C₂₉H₃₆O₁₅
• SMILES: COc1ccc(cc1OC)[C@@H]1CC(=O)c2c(O)cc(OC3OC(COC4OC(C)C(O)C(O)C4O)C(O)C(O)C3O)cc2O1
• Target: PKC|||Akt
• Solubility: DMSO:50 mg/mL (80.05 mM);Ethanol:< 1 mg/mL (insoluble or slightly soluble);H2O:insoluble;10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (3.2 mM)

Bioactivity

• In Vivo:
  Methyl Hesperidin can bind to human serum albumin, with a binding constant between 18 and 34 mM. Long-term carcinogenicity studies have demonstrated that Methyl Hesperidin has no carcinogenic effects on B6C3F1 mice after 96 weeks of feeding. Additionally, Methyl Hesperidin, in conjunction with Hesperidin, can inhibit the phosphorylation of Akt and PKC, resulting in decreased expression of TNF-α-induced VCAM-1.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Akt, Methyl Hesperidin, MethylHesperidin, Methyl-Hesperidin, inhibit, Inhibitor, PKC

Compound Identifiers

PubChem CID

71306786