Methoxy-X04

SKU: orb1745269

Description

Methoxy-X04 is a fluorescent Congo red derivative designed for imaging amyloid-β plaques. This brain-permeable probe is widely used for in vivo and in vitro detection and quantification of Aβ pathology in Alzheimer's disease research models.

Research Area

Neuroscience

Key Properties

• CAS Number: 863918-78-9
• MW: 344.4
• Purity: 98.96% (May vary between batches)
• Formula: C₂₃H₂₀O₃
• SMILES: COc1cc(\C=C\c2ccc(O)cc2)ccc1\C=C\c1ccc(O)cc1
• Target: Beta Amyloid,Others
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:1 mg/mL (2.9 mM);DMSO:37.14 mg/mL (107.84 mM)

Bioactivity

• In Vivo:
  In PS1/APP mice, a single i.v. injection of 5 to 10 mg/kg Methoxy-X04 distinguished individual plaques from brain fluorescent images, within 30 to 60 min after treatment. A single i.p. injection of 10 mg/kg Methoxy-X04 also produced high contrast images of plaques and cerebrovascular amyloid in PS1/APP mouse brains .
• In Vitro:
  In in vitro binding studies, compared with Chrysamine-G (Ki = 25.3 nM), Methoxy-X04 exhibited similar binding affinity for Aβ fibrils (Ki = 26.8 nM) . On brain slices of 12-month-old APP-PS1 (dE9) mice, 145 μM Methoxy-X04 was used for labeling fibrillary amyloid deposits .

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Methoxy X04, MethoxyX04, Methoxy-X04, Methoxy-X-04

Compound Identifiers

PubChem CID

16049314