MEN 11270

SKU: orb1679349

Description

This potent, conformationally constrained cyclic peptide is a selective B2 bradykinin receptor antagonist (pKi = 10.3) derived from HOE 140. It effectively blocks bradykinin-induced hypotension and bronchoconstriction in vivo and shows high selectivity over 29 other receptors and ion channels, making it a valuable tool for cardiovascular and inflammatory research.

Research Area

Signal Transduction

Key Properties

• Target: Bradykinin Receptor
• CAS Number: 235082-52-7
• MW: 1299.56
• Formula: C₆₀H₉₀N₂₀O₁₁S
• SMILES: O=C1N2[C@@]3([C@](C[C@]2(C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCC[C@H](NC([C@H](CC4=CC=CS4)NC(CNC(=O)[C@H]5N(C(=O)[C@H]6N(C([C@@H](NC([C@@H](CCCNC(=N)N)N)=O)CCCNC(=N)N)=O)CCC6)C[C@H](O)C5)=O)=O)C(=O)N7[C@@]1(CC=8C(C7)=CC=CC8)[H])[H])(CCCC3)[H])[H]

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

9812468