Mefenidil

SKU: orb1696167

Description

Mefenidil (McN-2378) is a selective cerebral vasodilator that elevates cerebral blood flow without increasing cerebral oxygen consumption, as demonstrated in canine anesthesia studies. This property makes it a useful research tool for investigating cerebrovascular physiology and pharmacology in vivo.

Research Area

Cell Biology, Molecular Biology, Neuroscience, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 58261-91-9
• MW: 197.24
• Purity: 98.17% (May vary between batches)
• Formula: C₁₂H₁₁N₃
• SMILES: C(C#N)C=1NC(=NC1C)C2=CC=CC=C2
• Target: DNA/RNA Synthesis,Adrenergic Receptor,Others
• Solubility: DMSO:50 mg/mL (253.5 mM)

Bioactivity

• In Vivo:
  Mefenidil (0.025, 0.25, and 2.5 mg/min/kg; i.v. infusion for 10 min; dogs) decreased systemic vascular resistance at 0.25 mg/min/kg without a change in CBF. At the highest infusion rate, CBF increased by 54 +/- 15% (+/- S.E.; n = 9) accompanied by a 9-mm Hg rise in intracranial pressure and a 14-mm Hg fall in mean aortic pressure. However, cardiac output increased by 68 +/- 8%, which was distributed primarily to right ventricle (541 +/- 95%), left ventricle (488 +/- 109%), small intestine (136 +/- 31%) and large intestine (57 +/- 15%). Within the brain, the thalamic and brainstem regions had larger increases in blood flow than the cerebellum and cerebrum. The caudate nucleus had a greater percentage of response than white matter. Using the cerebral venous outflow technique in another series of seven dogs, mefenidil (40-mg/kg i.v. bolus) produced a 20 +/- 8% increase in CBF with no change in O2 uptake. These data show that mefenidil is capable of increasing CBF in healthy brains without stimulating O2 uptake. However, the clinical usefulness of mefenidil as a cerebral vasodilator may be limited by the accompanying arterial hypotension due to systemic vasodilation, which was most prominent in the heart and gut.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Mefenidil, McN 2378, McN2378, McN-2378, DNASynthesis, DNA Synthesis, CBF, RNA Synthesis, RNASynthesis

Compound Identifiers

PubChem CID

65475