MDL-811

SKU: orb1942935

Description

MDL-811 is a potent and selective allosteric activator of SIRT6, enhancing its deacetylase activity toward histone H3 at K9, K18, and K56. This small molecule is a valuable research tool for investigating SIRT6's role in cellular senescence, DNA repair, and metabolism, with applications in colorectal cancer and aging-related disease studies in vitro and in vivo.

Research Area

Epigenetics & Chromatin, Molecular Biology

Key Properties

• CAS Number: 2275619-98-0
• MW: 681.42
• Formula: C₂₅H₂₅BrCl₂FN₃O₅S₂
• SMILES: S(NC1=C(C)C=C(F)C(Br)=C1)(=O)(=O)C2=C(CN3[C@H](C)COCC3)C=C(NS(=O)(=O)C4=CC(Cl)=CC(Cl)=C4)C=C2
• Target: Sirtuin

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

169450636