MC3138

SKU: orb2646186

Description

MC3138 is a potent and selective small molecule activator of SIRT5. It has demonstrated antitumor activity in pancreatic ductal adenocarcinoma (PDAC) cell lines in vitro, making it a valuable research tool for studying SIRT5 biology and oncology in cellular models.

Research Area

Epigenetics & Chromatin, Molecular Biology

Key Properties

• CAS Number: 1844889-12-8
• MW: 435.47
• Formula: C₂₅H₂₅NO₆
• SMILES: O=C(OCC)C1=CN(C=C(C(=O)OCC)C1C=2C=CC=C(OC)C2)C(=O)C=3C=CC=CC3
• Target: Sirtuin
• Solubility: DMSO:160 mg/mL (367.42 mM);10% DMSO+90% Corn Oil:5 mg/mL (11.48 mM)

Bioactivity

• In Vivo:
  The maximum plasma concentration and half-life of MC3138 are approximately 230 μM and 5.059 hours, respectively. GOT activity was significantly reduced in PDX xenograft tumor mouse models treated with MC3138 (100-200 μM).
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• In Vitro:
  MC3138 (10 μM, 24 h) inhibited lysine acetylation of GOT1 protein and decreased its enzyme activity in PDAC cells. Treated with MC3138 (50 μM, 24 or 48 h), MDA-MB-231 and CAL-62 cells, MC3138 reduced HIF-1α basal expression in MDA-MB-231 wt cells, but not in GLS1 silenced cells. MC3138 decreased PDAC cell viability, with IC50 values ranging from 25.4 μM to 236.9 μM.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

MC 3138

Compound Identifiers

PubChem CID

155524917