MC1742

SKU: orb1694331

Description

MC1742

Research Area

Cell Biology, Epigenetics & Chromatin, Molecular Biology

Key Properties

• CAS Number: 1776116-74-5
• MW: 395.48
• Purity: 99.20% (May vary between batches)
• Formula: C₂₁H₂₁N₃O₃S
• SMILES: O=C1N=C(SCCCCC(=O)NO)NC(=C1)C=2C=CC(=CC2)C=3C=CC=CC3
• Target: HDAC,Apoptosis
• Solubility: DMSO:160 mg/mL (404.57 mM)

Bioactivity

• Target IC50:
  HDAC11:0.1 μM|HDAC3:0.02 μM|HDAC10:0.04 μM|HDAC8:0.61 μM|HDAC6:0.007 μM|HDAC2:0.11 μM|HDAC1:0.1 μM
• In Vitro:
  MC1742 is a potent HDAC inhibitor with IC50 values of 0.1 μM, 0.11 μM, 0.02 μM, 0.007 μM, 0.61 μM, 0.04 μM, and 0.1 μM for HDAC1, HDAC2, HDAC3, HDAC6, HDAC8, HDAC10, and HDAC11, respectively.MC1742 was able to increase the levels of acetylated-H3 and acetylated microtubule proteins and inhibit the proliferation of cancer stem cells. MC1742 (0.5 and 2 μM; 24 h) was able to enhance acetylation levels in a dose-dependent manner, as evidenced by patchy nuclear staining of acetylated histone H3. MC1742 (0.5, 1 and 2 μM; 24, 48 and 72 h) significantly induced apoptosis in all cancer stem cell cultures. MC1742 (0.025-0.5 μM; 14 days) was able to significantly promote bone vesicle formation with a dose-dependent effect.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Apoptosis, HDAC, MC1742, MC-1742, MC 1742

Compound Identifiers

PubChem CID

136173089