MC-Val-Cit-PAB-MMAF

SKU: orb1988047

Description

MC-Val-Cit-PAB-MMAF is a cleavable linker-payload for constructing antibody-drug conjugates (ADCs). Its MMAF component inhibits tubulin polymerization, inducing apoptosis in target cells. This construct is widely used in oncology research for evaluating ADC efficacy in both in vitro cytotoxicity assays and in vivo xenograft models.

Research Area

Pharmacology & Drug Discovery

Key Properties

• CAS Number: 863971-17-9
• MW: 1330.61
• Formula: C₆₈H₁₀₃N₁₁O₁₆
• SMILES: [H][C@]([C@@H](C)CC)([C@@H](CC(=O)N1CCC[C@@]1([H])[C@H](OC)[C@@H](C)C(=O)N[C@@H](Cc1ccccc1)C(O)=O)OC)N(C)C(=O)[C@@H](NC(=O)[C@H](C(C)C)N(C)C(=O)OCc1ccc(NC(=O)[C@H](CCCNC(N)=O)NC(=O)[C@@H](NC(=O)CCCCCN2C(=O)C=CC2=O)C(C)C)cc1)C(C)C
• Target: PROTAC Linker,Drug-Linker Conjugates for ADC

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

56597792