MC-GGFG-AM-(10Me-11F-Camptothecin)

SKU: orb1982290

Description

MC-GGFG-AM-(10Me-11F-Camptothecin) is a linker-payload conjugate for constructing ZW251, a GPC3-targeting antibody-drug conjugate (ADC). This ADC utilizes a cleavable GGFG linker to deliver a camptothecin topoisomerase I inhibitor, demonstrating potent in vitro activity including internalization and bystander killing in hepatocellular carcinoma models.

Research Area

Molecular Biology

Key Properties

• CAS Number: 2873460-70-7
• MW: 1038.04
• Formula: C₅₁H₅₆FN₉O₁₄
• SMILES: C(NC(OCCOCNC(CNC([C@H](CC1=CC=CC=C1)NC(CNC(CNC(CCCCCN2C(=O)C=CC2=O)=O)=O)=O)=O)=O)=O)C3=C4C(C=5N(C4)C(=O)C6=C(C5)[C@](CC)(O)C(=O)OC6)=NC=7C3=CC(C)=C(F)C7
• Target: Drug-Linker Conjugates for ADC

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

166138783