Mavoglurant

SKU: orb3132236

Description

Mavoglurant (AFQ056) is a potent, selective, non-competitive, and orally active metabotropic glutamate receptor 5 (mGluR5) antagonist with an IC50 of 30 nM, demonstrating greater than 300-fold selectivity over 238 tested targets, and it is widely applied in research on Fragile X syndrome and L-dopa-induced dyskinesias in Parkinson’s disease, while Mavoglurant incorporated alkyne functional group, which enables copper-catalyzed azide–alkyne cycloaddition click chemistry, facilitating target engagement and molecular tracking studies.

Research Area

Pharmacology & Drug Discovery

Key Properties

• CAS Number: 543906-09-8
• MW: 313.39
• Purity: 99.91% (May vary between batches)
• Formula: C₁₉H₂₃NO₃
• SMILES: C(#CC1=CC(C)=CC=C1)[C@@]2(O)[C@]3([C@](N(C(OC)=O)CC3)(CCC2)[H])[H]
• Target: Cholecystokinin Receptor

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

Cholecystokinin Receptor