MAO-IN-M30 dihydrochloride

SKU: orb1692367

Description

MAO-IN-M30 dihydrochloride is a potent, brain-penetrant, and orally active dual inhibitor of MAO-A/B (IC50 < 0.1 µM) with iron-chelating and antioxidant properties. It demonstrates neuroprotective effects in Parkinson's disease models, elevating brain monoamine levels, which supports its investigation as a multifunctional therapeutic candidate for neurodegenerative disorders.

Research Area

Neuroscience

Key Properties

• CAS Number: 64821-19-8
• MW: 299.2
• Purity: 99.83%
• Formula: C₁₄H₁₆Cl₂N₂O
• SMILES: Cl.Cl.CN(CC#C)Cc1ccc(O)c2ncccc12
• Target: Monoamine Oxidase
• Solubility: DMSO:1.8 mg/mL (6.02 mM)

Bioactivity

• Target IC50:
  MAO-B:57 nM (IC50)|MAO-A:37 nM (IC50)
• In Vivo:
  MAO-IN-M30 (0.5-2.5 mg/kg; p.o.; once daily for 14 consecutive days) exhibits neuroprotective activities .
• In Vitro:
  MAO-IN-M30 (0.25 nM; 72 hours) significantly increased cell viability to ~90% after exposure to Dexamethasone and reduced the occurrence of fragmented DNA compared to the dexamethasone-treated group in SH-SY5Y cells. Additionally, MAO-IN-M30 (0-10 μM; 24 hours) enhances PC12 cell survival.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

monoamine oxidase, MonoamineOxidase, Monoamine Oxidase, M 30, M 30 Dihydrochloride, M 30 dihydrochloride, M30, M-30, M30 Dihydrochloride, M-30 Dihydrochloride, MAO-IN-M30, MAO-IN-M30 Dihydrochloride

Compound Identifiers

PubChem CID

71311622