MAO-B-IN-5

SKU: orb1685230

Description

MAO-B-IN-5 is a potent, selective, and orally bioavailable monoamine oxidase B inhibitor (IC50 = 0.204 µM). It is a research compound for investigating Parkinson's disease pathology, with applications in both in vitro enzymatic assays and in vivo PD model studies.

Research Area

Neuroscience

Key Properties

• CAS Number: 849909-77-9
• MW: 328.38
• Purity: 97.68% (May vary between batches)
• Formula: C₁₉H₂₁FN₂O₂
• SMILES: C(N1[C@H](C(N)=O)CCC1)C2=CC=C(OCC3=CC(F)=CC=C3)C=C2
• Target: Others,Monoamine Oxidase

Bioactivity

• Target IC50:
  MAO-A:0.204 μM|MAO-B:34.190 μM
• In Vivo:
  MAO-B-IN-5 demonstrates oral bioavailability (F=13.6%) in rats when administered at doses of 1 mg/kg intravenously (i.v.) and 5 mg/kg orally (p.o.). The pharmacokinetic profile of MAO-B-IN-5 in Sprague-Dawley (SD) rats is detailed, with the compound showing a maximum concentration (Cmax) of 809 ng/mL and an area under the curve (AUC) of 347 ng·h/mL following a 1 mg/kg intravenous dose; the half-life (T1/2) is 0.37 hours, volume of steady state (Vss) is 1.11 h, and clearance (Cl) is 47.1 mL/min/kg. Orally administered at a dose of 5 mg/kg, MAO-B-IN-5 has a Cmax of 163 ng/mL, an AUC of 284 ng·h/mL, and a T1/2 of 1.27 hours, with an oral bioavailability of 16.3%.
• In Vitro:
  MAO-B-IN-5 (compound D0) exhibits inhibitory activity against MAO, with IC50 values of 34.190 μM for MAO-A and 0.204 μM for MAO-B in Sf9 cells .

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

MAOBIN5, MAO-B-IN-5, MAO B IN 5

Compound Identifiers

PubChem CID

11324918