Mal-amide-PEG8-Val-Cit-PAB-OH

SKU: orb3022083

Description

Mal-amide-PEG8-Val-Cit-PAB-OH is a cleavable ADC linker, featuring a maleimide group, a hydrophilic PEG spacer, a Val-Cit dipeptide, and a PAB moiety. The maleimide group allows covalent bonding to free thiols on cysteine residues of proteins. The Val-Cit dipeptide is cleaved intracellularly by cathepsins to facilitate payload delivery via the PAB structure.

Key Properties

• CAS Number: 2387738-43-2
• MW: 954.072
• Formula: C₄₄H₇₁N₇O₁₆
• SMILES: N(C([C@@H](NC([C@@H](NC(CCOCCOCCOCCOCCOCCOCCOCCOCCNC(CCN1C(=O)C=CC1=O)=O)=O)[C@@H](C)C)=O)CCCNC(N)=O)=O)C2=CC=C(CO)C=C2
• Target: ADC Linker

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

ADC Linker