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7-Methyl-guanosine-5'-triphosphate sodium

SKU: orb1982157

Description

m7GTP sodium salt is a cap analog that competitively inhibits translation initiation by binding to eIF4E. It is widely used in vitro to study cap-dependent translation mechanisms and has been employed in research exploring mRNA metabolism and cellular stress responses.

Research Area

Cell Biology, Molecular Biology

Images & Validation

Key Properties

MWC11H18N5O14P3.xNa
FormulaC11H18N5O14P3.xNa
TargetOthers
SolubilityH2O:200 mg/mL

Bioactivity

In Vitro
m7GTP sodium acts as a competitive inhibitor of the eukaryotic translation initiation factor eIF4E. In various in vitro assays, m7GTP sodium is commonly used to block cap-dependent translation. For example, at 200 μM, m7GTP sodium effectively inhibits the binding of eIF4E to capped mRNAs in cell-free systems or lysates, impairing translation initiation.

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

7-Methyl-guanosine-5'-triphosphate sodium

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Key Properties

No computed properties available.

Protocol Information