M2698

SKU: orb1709207

Description

M2698

Research Area

Signal Transduction

Key Properties

• CAS Number: 1379545-95-5
• MW: 449.86
• Purity: 99.88%
• Formula: C₂₁H₁₉ClF₃N₅O
• SMILES: N([C@H](CN1CCC1)C2=CC(C(F)(F)F)=C(Cl)C=C2)C=3C4=C(C(C(N)=O)=CC=C4)N=CN3
• Target: mTOR,S6 Kinase,Akt
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:4 mg/mL (8.89 mM);DMSO:112.5 mg/mL (250.08 mM)

Bioactivity

• Target IC50:
  Akt1:1 nM|p70 S6K:1 nM|Akt3:1 nM
• In Vivo:
  Gavage administration of M2698 (10-30 mg/kg) dose-dependently inhibits the growth of tumors and increases pAkt levels in tumor tissue. M2698 (30 mg/kg) causes tumor regression. M2698 (1-20 mg/kg) inhibits S6 phosphorylation in a dose-proportional manner over time.
• In Vitro:
  M2698 (0.3 nM-50 M) dose-dependently inhibits proliferation in breast tumor cell lines (IC50s: 0.02-8.5 µM). M2698 (0.3-1 µM) induces feedback loop phosphorylation on Akt and suppresses Akt and p70S6K activity in HCC1419 and MDA-MB-453 cells. M2698 inhibits indirectly pGSK3β and pS6 with IC50s of 17 and 15 nM.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Akt3, Akt1, MSC2363318A, p70S6K, M 2698, M2698, M-2698

Compound Identifiers

PubChem CID

89808643