m-PEG24-NHS ester

SKU: orb1988180

Description

m-PEG24-NHS ester is a heterobifunctional polyethylene glycol linker frequently employed in constructing PROTAC molecules. Its hydrophilic PEG spacer and amine-reactive NHS ester group facilitate the synthesis of degraders for both in vitro biochemical studies and in vivo pharmacological research.

Research Area

Pharmacology & Drug Discovery

Key Properties

• CAS Number: 2395839-96-8
• MW: 1214.39
• Purity: 99.67% (May vary between batches)
• Formula: C₅₄H₁₀₃NO₂₈
• SMILES: O=C(ON1C(=O)CCC1=O)CCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOC
• Target: PROTAC Linker

Bioactivity

• In Vitro:
  The NHS ester group of m-PEG24-NHS ester can react with primary amines on proteins, peptides, or oligonucleotides to form stable amide bonds, enabling PEGylation of the molecule and thereby increasing its water solubility and stability. Commonly used in the synthesis of antibody–drug conjugates (ADCs), protein modification, oligonucleotide modification, and PROTACs, where it serves as a linker to enhance the pharmacokinetic properties of the molecule.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Alkyl/ether, m PEG24 NHS ester, mPEG24NHS ester, m-PEG-24-NHS ester, m-PEG24-NHS ester, PEGs

Compound Identifiers

PubChem CID

89254876