m-PEG12-amine

SKU: orb1989199

Description

m-PEG12-amine is a non-cleavable polyethylene glycol linker with 12 repeating units. It is widely utilized in constructing PROTAC degraders for targeted protein knockdown and in developing stable antibody-drug conjugates (ADCs) for both in vitro and in vivo therapeutic research.

Research Area

Pharmacology & Drug Discovery

Key Properties

• CAS Number: 1977493-48-3
• MW: 559.69
• Purity: >99.99% (May vary between batches)
• Formula: C₂₅H₅₃NO₁₂
• SMILES: C(OCCOCCOCCOCCOCCOCCN)COCCOCCOCCOCCOCCOC
• Target: PROTAC Linker,ADC Linker
• Solubility: DMSO:90 mg/mL (160.8 mM)

Bioactivity

• In Vitro:
  PROTACs, or proteolysis-targeting chimeras, are composed of two distinct ligands joined by a linker. One of these ligands binds to a specific protein target, while the other binds to an E3 ubiquitin ligase. When the PROTAC binds to both the target protein and the E3 ligase, it triggers the ubiquitin-proteasome system within cells to degrade the target protein, thereby providing a mechanism for targeted protein degradation.

Storage & Handling

• Storage: store at low temperature,keep away from direct sunlight | Pure form: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

ADCLinker, ADC linker, ADC Linker, Non-cleavable, mPEG12amine, m-PEG-12-amine, m-PEG12-amine, m PEG12 amine, PEGs, PROTAC Linkers

Compound Identifiers

PubChem CID

51340958