LY2955303

SKU: orb1308098

Description

LY2955303

Research Area

Cell Biology, Metabolism Research

Key Properties

• CAS Number: 1433497-19-8
• MW: 578.74
• Purity: 99.85%
• Formula: C₃₆H₄₂N₄O₃
• SMILES: CN1CCN(CC1)C(=O)c1ccc(cc1)-n1nc(cc1-c1cc(cc(c1)C(C)(C)C)C(C)(C)C)-c1ccc(cc1)C(O)=O
• Target: Retinoid Receptor,Autophagy
• Solubility: DMSO:25 mg/mL (43.2 mM)

Bioactivity

• Target IC50:
  RARγ:1.09 nM(ki)
• In Vivo:
  A single dose of LY2955303(oral) showed a dose-response effect in rats with different weight-bearing reductions with an ED50 of 0.72 mg/kg.
• In Vitro:
  The functional Ki for RARγ is 7.1±4.9 nM. The binding Kis of LY2955303 for RARα, RARβ, and RARγ are >1700, >2980, and 1.09 nM, respectively.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Autophagy, inhibit, LY2955303, LY-2955303, LY 2955303, Inhibitor, RAR/RXR, RARγ, Retinoid Receptor, Retinoid X receptors, Retinoic acid receptors, RetinoidReceptor

Compound Identifiers

PubChem CID

71552369