LY2940094

SKU: orb1308105

Description

LY2940094 is a potent, selective, and orally bioavailable nociceptin receptor antagonist (Ki=0.105 nM). It reduces ethanol self-administration in preclinical models, supporting its research use in studying addiction neurobiology and substance use disorders in both in vitro and in vivo systems.

Research Area

Metabolism Research, Neuroscience, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 1307245-86-8
• MW: 480.96
• Purity: 99.60% (May vary between batches)
• Formula: C₂₂H₂₃ClF₂N₄O₂S
• SMILES: Cc1nn(cc1CN1CCC2(CC1)OCC(F)(F)c1cc(Cl)sc21)-c1ncccc1CO
• Target: Opioid Receptor
• Solubility: DMSO:41.67 mg/mL (86.64 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (4.16 mM)

Bioactivity

• Target IC50:
  NOP receptor: 0.166 nM(Kb)|NOP receptor:(ki)0.105 nM
• In Vivo:
  In Indiana Alcohol-Preferring (P) and Marchigian Sardinian Alcohol-Preferring (msP) rats, LY-2940094 (3, 10, or 30 mg/kg; 2-3 mL/kg; orally daily; for 4 days) dose-dependently decreases homecage ethanol self-administration, without affecting food/water intake or locomotor activity.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

penetrate, self-administration, orally ethanol, BTRX 246040, BTRX246040, BTRX-246040, brain, disorder, depressive, major, OpioidReceptor, Opioid Receptor, LY 2940094, LY2940094, LY-2940094, Inhibitor, NOP receptor, inhibit

Compound Identifiers

PubChem CID

52914971