LY223982

SKU: orb1707044

Description

LY223982 is a potent and selective antagonist of the leukotriene B4 (LTB4) receptor. It effectively blocks LTB4-mediated neutrophil activation and transient leukopenia, making it a valuable tool for studying inflammatory pathways in both in vitro cellular assays and in vivo disease models.

Research Area

Immunology & Inflammation, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 117423-74-2
• MW: 502.56
• Purity: 99.86% (May vary between batches)
• Formula: C₃₀H₃₀O₇
• SMILES: C(CC(O)=O)C1=C(OCCCC/C=C/C2=CC=C(OC)C=C2)C=CC(C(=O)C3=CC(C(O)=O)=CC=C3)=C1
• Target: LTR,Leukotriene Receptor
• Solubility: DMSO:80 mg/mL (159.18 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:3.3 mg/mL (6.57 mM)

Bioactivity

• Target IC50:
  LTB4:13.2 nM
• In Vivo:
  LY223982 inhibits transient leukopenia induced by LTB4 (ED50, 3 mg/kg) in rabbits, but not by FMLP. LY223982 has no agonist activity in any test system.
• In Vitro:
  LY223982 is 189-fold more efficient than 35S-N-formyl-L-formyl-L-leucyl-L-phenylalanine (FMLP) in displacing [3H]LTB4 from its corresponding receptor on human neutrophils. The concentration that inhibits [3H]LTB4 displacement by 50% (IC50 value of 13.2 nM) is only 6.8-fold higher than that of non-radioactive LTB4.

Storage & Handling

• Storage: store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

LTB4, LY223982, LY-223982, LY 223982, CGS 23131, CGS23131, CGS-23131, SKF 107324, SKF107324, SKF-107324

Compound Identifiers

PubChem CID

6444688