LY 456236 hydrochloride

SKU: orb1704386

Description

LY 456236 hydrochloride is a potent, selective, and orally active non-competitive mGlu1 receptor antagonist (IC50=143 nM). It also inhibits inositol phosphate hydrolysis (IC50=0.145 µM) and EGFR (IC50=0.91 µM). This compound is a valuable research tool for studying mGlu1 receptor function in neurological disorders, with applications in both in vitro and in vivo models.

Research Area

Cardiovascular Research, Neuroscience, Signal Transduction

Key Properties

• CAS Number: 338736-46-2
• MW: 317.77
• Purity: 99.95% (May vary between batches)
• Formula: C₁₆H₁₆ClN₃O₂
• SMILES: Cl.COc1ccc(Nc2ncnc3ccc(OC)cc23)cc1
• Target: EGFR,GluR
• Solubility: DMSO:225 mg/mL (708.06 mM)

Bioactivity

• Target IC50:
  mGlu1:0.145 μM|EGFR:0.91 μM
• In Vivo:
  LY456236 exhibits anticonvulsant effects in mice (3-100 mg/kg; i.p.; once) and rats (10-60 mg/kg; oral; once).
• In Vitro:
  LY456236 (2 μM; 30 min) reduces the proliferation of DHPG-stimulated OCCM-30 cells.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

MPMQ hydrochloride, MPMQ Hydrochloride, mGluR, LY 456236 Hydrochloride, LY456236 Hydrochloride, LY-456236 Hydrochloride, EGFR

Compound Identifiers

PubChem CID

9926998