LY 2389575 hydrochloride

SKU: orb1745250

Description

LY2389575 hydrochloride is a selective, non-competitive mGlu3 negative allosteric modulator (IC50 = 190 nM). It is used in Alzheimer's disease research, where it has been shown in experimental models to upregulate Mrc1 and exacerbate β-amyloid toxicity, providing a tool for studying disease mechanisms.

Research Area

Neuroscience

Key Properties

• CAS Number: 885104-09-6
• MW: 438.58
• Purity: 99.45% (May vary between batches)
• Formula: C₁₅H₁₆BrCl₃N₄
• SMILES: N(CC1=C(Cl)C=C(Cl)C=C1)[C@@H]2CN(CC2)C=3N=CC(Br)=CN3.Cl
• Target: GluR,Beta Amyloid
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:3.3 mg/mL (7.52 mM);DMSO:90 mg/mL (205.21 mM);Methanol:7.5 mg/mL (17.1 mM)

Bioactivity

• Target IC50:
  mGluR3:190 nM
• In Vitro:
  LY2389575 hydrochloride (5 μM; 1 h) induces an increase in Mrc1 levels in microglial cells.

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

βAmyloid, β Amyloid, bAmyloid, Aβ, b Amyloid, BetaAmyloid, Beta Amyloid, LY 2389575 hydrochloride, LY 2389575 Hydrochloride, LY2389575 Hydrochloride, LY-2389575 Hydrochloride, mGluR

Compound Identifiers

PubChem CID

11503054